ERK Activation Inhibitor Peptide II, Cell-Permeable
$134.00
- $536.00
| ERK Activation Inhibitor Peptide II, Cell-Permeable |
| MTPTAT-G-MEK113, H-GYGRKKRRQRRR-G-MPKKKPTPIQLNP-NH2 |
| A cell-permeable 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that is fused to the HIV-TAT membrane translocating peptide (MTP) sequence via a glycine linker. Acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 210 nM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC50 = 29 µM). Does not affect the activation of JNKs or p38. |
| Cat No: | CP789 |
| Peptide Sequence | H-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2 |
| Molecular mass | 3146.8 |
| Protect from Light | Yes |
| Hygrocopic | Yes |
| Packaged under inert gas | Yes |
| Cell Permeable: | Yes |
| Purity | ≥95% by HPLC |
| Solubility | DMSO or H2O |
| Chemical formula | C136H241N53O31S |
| Storage | -20°C |